Evidence map›Paper›PMID 42257745›Full record

Observational studyBreast cancer research and treatment2026

Risk of malignancy after diagnosis of radial sclerosing lesion without atypia.

Lorena Beatriz Delgado Casanova, Sagar Dhamne, Erika Resetkova, Mary S Guirguis, Avanthi Puvvala, Therese B Bevers, Isabelle Bedrosian, Lei Huo, Kerollos Nashat Wanis

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Breast cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lorena Beatriz Delgado CasanovaDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1434, Houston, TX, 77030, USA.
Sagar DhamneDepartment of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Erika ResetkovaDepartment of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mary S GuirguisDepartment of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Avanthi PuvvalaDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1434, Houston, TX, 77030, USA.
Therese B BeversDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Isabelle BedrosianDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1434, Houston, TX, 77030, USA.
Lei HuoDepartment of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kerollos Nashat WanisDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1434, Houston, TX, 77030, USA. kwanis@mdanderson.org.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
CANCER PREVENTION EDUCAT--STUDENT RESEARCH EXPERIENCESR25CA056452 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shine Chang · 1992 to 2026
$6.9M
NCI NIH HHS MD Anderson Cancer Center Center Support Grant P30CA016672NCI NIH HHS P30 CA016672NCI NIH HHS R25 CA056452
6 · The paper itself

Abstract

purposeSurgical excision of radial sclerosing lesions (RSLs) has historically been recommended to rule out malignancy. Contemporary guidelines support imaging surveillance instead whenever these lesions are "adequately sampled." However, uncertainty exists around what suffices for sampling prior to observation, and the outcomes of imaging surveillance.

methodsWe conducted an observational cohort study including all RSLs diagnosed on image-guided needle biopsy performed at our institution from 2020 to 2025. We excluded lesions with a concurrent diagnosis of invasive cancer, ductal carcinoma in situ, or epithelial atypia in the ipsilateral breast. For lesions that underwent repeat percutaneous biopsy or surgical excision, we estimated the probability that additional sampling revealed malignancy. For the entire population, whether excision was performed or not, we estimated the cumulative incidence of malignancy at the site of RSL during follow-up.

resultsA total of 419 RSLs were diagnosed in 390 patients. 262 (62.5%) lesions were diagnosed by stereotactic-guided vacuum-assisted biopsy (VAB), 100 (23.9%) by MRI-guided VAB, and 57 (13.6%) by ultrasound-guided core needle biopsy. During initial work-up or follow-up, 35 lesions underwent repeat image-guided biopsy and 28 underwent surgical excision. None of these additional sampling procedures revealed malignancy. The estimated 3-year cumulative incidence of malignancy at the RSL site was 0% (95% CI: 0, 2.0%).

conclusionsThese findings support a management strategy of imaging surveillance when radiologic-pathologic concordance is established. Even for less extensively sampled lesions, routine repeat biopsy or surgical excision may not be necessary for RSLs without atypia.

Indexed as

Breast NeoplasmsAdultAgedBiopsy, Large-Core NeedleBreastFemaleHumansImage-Guided BiopsyIncidenceMiddle AgedSclerosisBenign breast lesionsComplex sclerosing lesionImaging surveillanceRadial scarRadial sclerosing lesionSurgical excision

Identifiers

PMID42257745
PMCPMC13246926

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.