ArticleInternational urogynecology journal2026
Histological Microstructure and In Vitro Mechanical Properties of Postmenopausal Ewe Perineal Body With and Without Estrogen Replacement Therapy.
Article in International urogynecology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introduction and hypothesisThe objective was to assess the regional variability, mechanical properties, and histological composition of the perineal body in postmenopausal ewes with and without delayed estrogen replacement therapy (ERT), providing data relevant for pelvic floor modeling and the understanding of menopausal tissue changes.
methodsThe fibromuscular layer of the central tendon of the perineal area between the rectum and vagina was used for the study. We analyzed 24 specimens from 8 postmenopausal ewes with ERT (initiated 180 days after ovariectomy and continued for 100 days)-POST-ERT group-and 21 specimens from 7 ewes without ERT-POST group, all 280 days after ovariectomy. Uniaxial tensile tests determined the Young's moduli in small (E
resultsMechanical parameters did not differ significantly between groups (E
conclusionsDespite prolonged estrogen deprivation, the perineal body maintained mechanical integrity. Structural changes, particularly increased collagen and elastin after delayed ERT, suggest adaptive remodeling but do not translate into measurable biomechanical reinforcement within the studied timeframe. The results provide parameters for finite element modeling of pelvic floor disorders.
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