Evidence map›Paper›PMID 42257719›Full record

ArticlePediatric surgery international2026

Comparison of non-invasive liver fibrosis indicators for biliary atresia.

Yifan Yang, Jingying Jiang, Jin Zhou, Di Chen, Jie Zhang, Gong Chen, Rui Dong, Shan Zheng

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yifan Yang *Department of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wan Yuan Rd., Shanghai, 201102, China.
Jingying Jiang *Department of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wan Yuan Rd., Shanghai, 201102, China.
Jin ZhouDepartment of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wan Yuan Rd., Shanghai, 201102, China.
Di ChenDepartment of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wan Yuan Rd., Shanghai, 201102, China.
Jie ZhangDepartment of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wan Yuan Rd., Shanghai, 201102, China.
Gong ChenDepartment of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wan Yuan Rd., Shanghai, 201102, China.
Rui DongDepartment of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wan Yuan Rd., Shanghai, 201102, China.
Shan ZhengDepartment of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wan Yuan Rd., Shanghai, 201102, China. szheng@shmu.edu.cn.

Funding

National Children's Medical Center Projects EKQM202402National Children's Medical Center Projects EKSJD202409National Children's Medical Center Projects EKYX202401National Natural Science Foundation of China 82270541Shanghai Municipal Health Commission 2025ZZ2018
6 · The paper itself

Abstract

purposeTo compare the value of non-invasive liver fibrosis indicators, including serum matrix metalloproteinase-7 (MMP-7), APRI, collagen-related proteins [hyaluronic acid (HA), type IV collagen (IV-C), type III procollagen N-terminal peptide (PIIIP), laminin] and shear wave elastography (SWE), in assessing liver fibrosis for biliary atresia (BA).

methodsA retrospective cohort study was conducted in BA infants from July 2020 to December 2023. Liver fibrosis was classified according to the Batts-Ludwig criteria.

resultsA total of 471 BA infants were included. Serum MMP-7, HA, IV-C, PIIIP, laminin, and SWE all correlated with liver fibrosis, with correlation coefficients of 0.4, 0.28, 0.37, -0.15, 0.16, and 0.46 (all P < 0.01), respectively. For severe fibrosis, the AUROC was 0.675 (95% CI: 0.622-0.728) at a cutoff value of 58.98 ng/ml for MMP-7, 0.719 (95% CI: 0.664-0.775) at a cutoff value of 547.05 for IV-C, and 0.732 (95% CI: 0.667-0.796) at a cutoff value of 1.35 m/s for SWE. Among the combined models, IV-C + MMP-7 achieved the higher performance (AUROC 0.756, 95% CI 0.700-0.811).

conclusionsNon-invasive serum markers and SWE all showed moderate value for fibrosis assessment in BA. SWE may be a promising and useful non-invasive tool, while selected serum biomarker combinations may provide complementary value for identifying severe fibrosis.

Indexed as

Biliary AtresiaLiver CirrhosisBiomarkersCollagen Type IVElasticity Imaging TechniquesFemaleHumansHyaluronic AcidInfantLamininMaleMatrix Metalloproteinase 7Peptide FragmentsProcollagenRetrospective StudiesBiomarkersCollagen Type IVHyaluronic AcidLamininMatrix Metalloproteinase 7Peptide FragmentsProcollagenprocollagen Type III-N-terminal peptideBiliary atresiaLiver fibrosisMatrix metalloproteinase-7Shear wave elastography

Identifiers

PMID42257719

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