Evidence map›Paper›PMID 42257687›Full record

ArticleEpilepsia2026

Compensatory rearrangement of parvalbumin interneuron voltage-gated sodium channel subunits in a mouse model of Dravet syndrome.

Ania K Dabrowski, Ala Somarowthu, Sophie R Liebergall, Damaris N Lorenzo, Ethan M Goldberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ania K DabrowskiDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-8978-7185
Ala SomarowthuDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Sophie R LiebergallDepartment of Neuroscience, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-6744-4835
Damaris N LorenzoDepartment of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-6856-2988
Ethan M GoldbergDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-7404-735X

Funding

Interneuron axonopathy underlies circuit dysfunction in a mouse model of Dravet syndromeR01NS110869 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ETHAN M GOLDBERG · 2019 to 2026
$3.5M
Cytoskeletal pathways of cerebellar dysregulation in neurodevelopmental disordersR01MH136674 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Damaris N Lorenzo · 2024 to 2026
$2.5M
Elucidating the synaptic interactome of the high risk autism gene ANK2R01MH127848 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Damaris N Lorenzo · 2022 to 2026
$2.2M
Role of Ankyrin-B in the Nervous SystemR01NS110810 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LORENZO, DAMARIS N · 2020 to 2024
$1.9M
A developmental mechanism of temperature-sensitive seizures towards therapeutic manipulationR01NS137604 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ETHAN M GOLDBERG · 2025 to 2026
$1.2M
Cellular and circuit function of Ndnf-expressing interneurons in a mouse model of a neurodevelopmental disorderF31NS132519 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LIEBERGALL, SOPHIE ROSE · 2023 to 2025
$124k
NIMH NIH HHS R01 MH127848NIMH NIH HHS R01MH127848NIMH NIH HHS R01 MH136674NIMH NIH HHS R01MH136674NINDS NIH HHS F31 NS132519NINDS NIH HHS F31NS132519NINDS NIH HHS R01 NS110810NINDS NIH HHS R01NS110810NINDS NIH HHS R01 NS110869NINDS NIH HHS R01NS110869NINDS NIH HHS R01 NS137604NINDS NIH HHS R01NS137604
6 · The paper itself

Abstract

Heterozygous loss-of-function variants in the gene SCN1A, which encodes the voltage-gated sodium channel (VGSC) pore-forming (α) subunit Na

Indexed as

Epilepsies, MyoclonicInterneuronsNAV1.1 Voltage-Gated Sodium ChannelParvalbuminsAction PotentialsAnimalsAxon Initial SegmentDisease Models, AnimalMiceNAV1.6 Voltage-Gated Sodium ChannelNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelParvalbuminsScn1a protein, mouseaxon initial segmentDravet syndromeNaV1.1NaV1.6SCN1Avoltage‐gated sodium channels

Identifiers

PMID42257687
PMCPMC13525587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.