Evidence map›Paper›PMID 42257521›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026

Fully Reversible Regulation of 8-17 DNAzyme Activity Using Nucleoside-Based Diarylethenes.

Jörn Bargstedt, Simon M Büllmann, Sophia Conwell, Andres Jäschke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jörn BargstedtInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0009-0009-8576-0431
Simon M BüllmannInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0000-0003-1031-4524
Sophia ConwellInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.
Andres JäschkeInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-4625-2655

Funding

Deutsche Forschungsgemeinschaft 794/12-1
6 · The paper itself

Abstract

Controlling enzyme activity with external triggers is a central goal in chemical biology. Light is an especially attractive stimulus because it is noninvasive, offers high spatiotemporal precision, and can reversibly modulate molecular function. In this study, we use nucleoside-based diarylethenes (DAEs) to achieve light-dependent control of the RNA-cleaving deoxyribozyme (DNAzyme) 8-17. Three high-performing DAE-modified 2'-deoxyuridines were incorporated at structurally informed positions within the DNAzyme. A single optimal combination, dU-Ph

Indexed as

DeoxyuridineDNA, CatalyticNucleosidesRNAUltraviolet RaysDeoxyuridineDNA, CatalyticNucleosidesRNARNA-cleaving DNA 8-178–17 DNAzymediarylethenesnucleosidesphotochromic DNAreversible regulation

Identifiers

PMID42257521
PMCPMC13587643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.