ArticleFuture science OA2026
Exposure to environmental toxicants and obstructive sleep apnea: a cross-sectional study.
Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
objectiveTo evaluate associations between environmental toxicant (ET) exposures and obstructive sleep apnea (OSA) using an exposome-wide approach.
methodsThis cross-sectional analysis included 13,161 participants from two NHANES cycles (2015-2016 and 2017-March 2020). Fifty-six toxicants across six classes (arsenic species, ethylene oxide, heavy metals, nicotine metabolites, VOC metabolites, and thyroid-disrupting compounds) were measured. OSA status was defined using a validated questionnaire based on self-reported symptoms. Exposome-wide association analysis (ExWAS) adjusted for sociodemographic, lifestyle, and clinical covariates, and restricted cubic spline (RCS) analysis characterized nonlinear exposure-response relationships.
resultsThe overall prevalence of OSA was 49% (
conclusionsNine ETs were significantly associated with OSA prevalence, with evidence of differential susceptibility by sex and age. These findings highlight environmental factors associated with OSA, which may serve as potential targets for future mechanistic research and public health interventions.
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