Anti-tumor Effect of Glycopeptides with Different Morphologies.

Qi He, Lintong Yao, Rongying Liu, Lin Yin, Guoliang Tang, Guang Yang, Zhijun Shi, Guosong Chen

Abstract read

In one paragraph

Article in Polymer science & technology (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qi HeThe State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.

Lintong YaoThe State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.

Rongying LiuThe State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.

Lin YinThe State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.

Guoliang TangDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

Guang YangDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

Zhijun ShiDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID https://orcid.org/0000-0003-2637-1320

Guosong ChenThe State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, China.ORCID https://orcid.org/0000-0001-7089-911X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor progression is intricately associated with dysregulated extracellular matrix (ECM) remodeling. Supramolecular fibers composed of biomolecules exhibit structural and functional characteristics reminiscent of the native ECM. Leveraging this similarity, the construction of such fibers within the pericellular space may reconstruct the dysregulated ECM and act as a promising anticancer strategy, by remodeling the interactions between tumor cells and their microenvironment. In this study, we systematically evaluated a series of self-assembled glycopeptide fibers for their ability to inhibit tumor cell proliferation and angiogenesis. A truncated glycopeptide fiber demonstrated significantly enhanced efficacy in modulating the tumor microenvironment compared to other variants. Preliminary mechanistic investigations were also conducted, which revealed that the anti-tumor effect may be attributed to the physical interaction between fibers and tumor cells, thereby providing valuable insights into the mode of action. These findings not only highlight the therapeutic potential of glycopeptide-based fibrils but also pave the way for innovative approaches in cancer treatment.

Identifiers

PMID42257186

DOI10.1021/polymscitech.5c00093

PMCPMC13052604

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.