ArticlePakistan journal of medical sciences2026
Prognostic value of brain natriuretic peptide and N-terminal pro b-type natriuretic peptide in patients with cardiac arrest: A systematic review and meta-analysis.
Article in Pakistan journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: The aim of the present study was to systematically review published evidence on the prognostic ability of brain natriuretic peptide (BNP) and N-terminal pro b-type natriuretic peptide (NT-proBNP) in patients with cardiac arrest. Methodology: This review searched PubMed, Embase, Scopus, and Cochrane databases for studies assessing mortality, survival to discharge, return of spontaneous circulation (ROSC), or neurological outcomes in cardiac arrest patients based on BNP or NT-proBNP. Search limits were from database inception to 20 Results: Eleven studies were eligible. Meta-analysis showed a statistically significant association between high baseline BNP levels and mortality after cardiac arrest (OR: 2.47 95% CI: 1.24, 4.92 I Conclusions: Evidence on the prognostic ability of BNP and NT-proBNP for cardiac arrest is preliminary. BNP and NT-proBNP may potentially predict poor neurological outcomes after cardiac arrest. Limited and inconsistent evidence also shows that there may be no association between baseline level of these markers and mortality. Data on ROSC and survival to discharge is scarce and conflicting and needs more studies for robust conclusions. Given the high heterogeneity and lack of stability of outcomes on sensitivity analysis, the results must be interpreted with caution.
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