Evidence map›Paper›PMID 42257064›Full record

ArticleCase reports in hematology2026

Outpatient Rescue With Stem Cells Boost for Refractory Hematotoxicity Following anti-BCMA CAR T-Cell Therapy: A Case Report.

Mehdi Loukhnati, Benjamin Hebraud, Marine Cazaux, Cécile Borel, Pierre Bories, Jean Alain Martignoles, Miguel Granell, Pierre Cougoul, Jeremie Dion, Lucie Oberic and 3 more

Abstract read
In one paragraph

Article in Case reports in hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mehdi LoukhnatiFaculty of Medicine and Pharmacy, Department of Hematology, Mohammed VI University Hospital, Cadi Ayyad University, Marrakesh, Morocco, uca.ma.ORCID https://orcid.org/0000-0003-0338-2756
Benjamin HebraudDepartment of Hematology, Toulouse University Cancer Institute - Oncopole, Toulouse, France.
Marine CazauxDepartment of Hematology, Toulouse University Cancer Institute - Oncopole, Toulouse, France.
Cécile BorelDepartment of Hematology, Toulouse University Cancer Institute - Oncopole, Toulouse, France.
Pierre BoriesDepartment of Hematology, Toulouse University Cancer Institute - Oncopole, Toulouse, France.
Jean Alain MartignolesDepartment of Hematology, Toulouse University Cancer Institute - Oncopole, Toulouse, France.
Miguel GranellDepartment of Hematology, Toulouse University Cancer Institute - Oncopole, Toulouse, France.
Pierre CougoulDepartment of Internal Medicine, Toulouse University Cancer Institute - Oncopole, Toulouse, France.
Jeremie DionDepartment of Internal Medicine, Toulouse University Cancer Institute - Oncopole, Toulouse, France.
Lucie ObericDepartment of Hematology, Toulouse University Cancer Institute - Oncopole, Toulouse, France.ORCID https://orcid.org/0000-0002-0039-1983
Anne HuynhDepartment of Hematology, Toulouse University Cancer Institute - Oncopole, Toulouse, France.
Illias TaziFaculty of Medicine and Pharmacy, Department of Hematology, Mohammed VI University Hospital, Cadi Ayyad University, Marrakesh, Morocco, uca.ma.
Aurore PerrotDepartment of Hematology, Toulouse University Cancer Institute - Oncopole, University of Toulouse, Toulouse, France.ORCID https://orcid.org/0000-0003-0131-8689

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged and refractory hematotoxicity is a severe complication of anti-BCMA CAR-T cell therapy, associated with substantial morbidity. When conventional supportive measures (transfusions and hematopoietic growth factors) fail, alternative strategies are urgently needed. We report the case of a 55-year-old man who developed persistent cytopenias after idecabtagene vicleucel. Reinfusion of cryopreserved autologous stem cells (stem cell boost), administered without conditioning chemotherapy, resulted in rapid and complete hematopoietic recovery after 14 days. This case highlights the potential of stem cell boost as a salvage approach for prolonged post-CAR-T hematotoxicity and underscores the need for prospective multicenter studies to standardize indications, timing, and procedures for this intervention.

Indexed as

anti-BCMACAR-T cellhematotoxicitystem cell boost

Identifiers

PMID42257064
PMCPMC13238238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.