Evidence map›Paper›PMID 42257052›Full record

ArticleVeterinary medicine international2026

Overcoming Batch Variability: A Chemically Defined XRS-Based System for Ovine In Vitro Embryo Production.

Yun Wang, Enci Wang, Qingqing Chen, Gulibanu Nuermaimaiti, Anan Shi, Ye Xiao, Yuheng Luo, Yakun He, Wenhui Pi, Chunhe Xiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary medicine international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yun WangCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.
Enci WangCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.
Qingqing ChenCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.
Gulibanu NuermaimaitiCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.
Anan ShiCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.
Ye XiaoCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.
Yuheng LuoCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.
Yakun HeCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.
Wenhui PiCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.ORCID https://orcid.org/0009-0000-0995-9064
Chunhe XiangCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China, shzu.edu.cn.ORCID https://orcid.org/0009-0009-0454-8907

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional IVM and IVF systems for sheep embryos rely on fetal bovine serum (FBS) and estrous sheep serum (ESS), which present challenges of batch variability, ethical concerns, and supply limitations. This study evaluated XRS Standard serum replacer as a complete substitute for both FBS and ESS in sheep IVEP. A 2 × 2 factorial design generated all four possible IVM/IVF combinations-FBS/ESS, FBS/XRS, XRS/ESS, and XRS/XRS (each additive at 10% v/v in IVM and IVF media). The FBS/ESS combination served as the conventional control. Cleavage rates (Day 2) and blastocyst development (Day 7) were quantified. XRS/XRS achieved 22.45% blastocyst rates-a 2.0-fold improvement over controls (11.00%,

Indexed as

in vitro fertilization (IVF)in vitro maturation (IVM)ovine embryosserum replacerthe 3Rs

Identifiers

PMID42257052
PMCPMC13238267

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.