Evidence map›Paper›PMID 42256976›Full record

ArticleClinical case reports2026

Trametinib Therapy for Hypertrophic Cardiomyopathy and Pulmonary Hypertension in a Child With RAF1-Related Noonan Syndrome (p.Ser257Leu): A Case Report.

C Noah Nilsson, Othman A Aljohani, Michael A Smith, Rachelle Durand, Inger Norlyk Sheyanth, Hythem Nawaytou, Elliot Stieglitz, Russel Valle, Sanjeev A Datar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

C Noah NilssonDepartment of Pediatrics University of California San Francisco California USA.ORCID https://orcid.org/0009-0006-8776-6982
Othman A AljohaniDepartment of Pediatrics University of California San Francisco California USA.
Michael A SmithDepartment of Pediatrics University of California San Francisco California USA.
Rachelle DurandDepartment of Radiology University of California San Francisco California USA.
Inger Norlyk SheyanthDepartment of Cardiothoracic Surgery Copenhagen University Hospital Copenhagen Denmark.
Hythem NawaytouDepartment of Pediatrics University of California San Francisco California USA.
Elliot StieglitzDepartment of Pediatrics University of California San Francisco California USA.
Russel ValleDepartment of Pediatrics University of California San Francisco California USA.
Sanjeev A DatarDepartment of Pediatrics University of California San Francisco California USA.

Funding

Research Training in Childhood CancerT32CA128583 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Alejandro Sweet-Cordero · 2007 to 2026
$6.0M
NCI NIH HHS T32 CA128583
6 · The paper itself

Abstract

This case describes a female infant with

Indexed as

hypertrophic cardiomyopathyMEK inhibitionNoonan syndromepulmonary hypertensionTrametinib

Identifiers

PMID42256976
PMCPMC13239823

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.