ArticleClinical case reports2026
AA Amyloidosis Resulting From Unintended Discontinuation of Rheumatoid Arthritis Therapy due to Cognitive Impairment.
Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Amyloid A (AA) amyloidosis is a serious complication of chronic inflammatory diseases, including rheumatoid arthritis (RA). A 78-year-old woman with advanced dementia developed progressive renal dysfunction following prolonged, unintentional RA treatment discontinuation. Laboratory evaluation demonstrated elevated inflammatory markers, serum AA levels, and proteinuria. Because renal biopsy was not feasible, an abdominal skin punch biopsy revealed AA amyloid deposition despite the absence of skin lesions. Low-dose glucocorticoids improved inflammatory markers; however, renal dysfunction persisted. This case highlights the risk of treatment interruption in cognitively impaired older adults and the diagnostic value of skin biopsy.
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