Evidence map›Paper›PMID 42256890›Full record

ArticleBioactive materials2026

A nucleic acid regulation strategy under mechanical stress for intervertebral disc degeneration treatment.

Wenchao Wang, Wenxiang Huo, Dingfei Qian, Peihong Hou, Cheng Su, Shengyao Sun, Yawei Yao, Jinlong Ma, Linhao Hou, Jiayan Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wenchao WangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Wenxiang HuoSchool of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 511400, China.
Dingfei QianDepartment of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China.
Peihong HouDepartment of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China.
Cheng SuDepartment of Orthopaedics, Zhoukou Orthopaedic Hospital, Zhoukou, 466000, China.
Shengyao SunDepartment of Neurology, The Seventh People's Hospital of Jinan, Jinan, 251409, China.
Yawei YaoDepartment of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China.
Jinlong MaSchool of Medicine, Nankai University, Tianjin, 300071, China.
Linhao HouDepartment of Orthopaedic, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Jiayan WuDepartment of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China.
Yongming ChenSchool of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 511400, China.
Fanqi HuDepartment of Orthopaedics, The Fourth Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China.
Tianyu ZhaoSchool of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 511400, China.
Xuesong ZhangSchool of Medicine, Nankai University, Tianjin, 300071, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nucleus pulposus (NP), the core shock-absorbing component of the intervertebral disc (IVD), plays a vital role in the pathogenesis of intervertebral disc degeneration (IVDD). Here, we uncover that degenerative NP tissue under mechanical stress is characterized by upregulated PIEZO1 and accumulation of cell-free DNA (cfDNA). Specific inhibition or knockout of PIEZO1 suppresses the cfDNA-induced NP degeneration. Mechanistically, PIEZO1-mediated calcium overload triggers mitochondrial DNA (mtDNA) leakage, initiating a cascade that culminates in MAFB-dependent activation of the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome pathway. Targeting the PIEZO1-cfDNA-MAFB-NLRP3 axis, we developed a hydrogel nano composite system (HA-F127@MCC950 SiNPs) containing amino-functionalized SiO

Indexed as

cfDNAIntervertebral disc degenerationMechanical stressNLRP3PIEZO1

Identifiers

PMID42256890
PMCPMC13234844

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.