ArticleMolecular and clinical oncology2026
Submental artery island flap for reconstruction of lateral oropharyngeal carcinoma in patients with severe anesthesiological risk factors: Functional and oncologic outcomes.
Article in Molecular and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The submental arterial island flap (SMIF) is used mostly for closing defects in the oral cavity, but also has its uses for oropharyngeal reconstruction. Since the duration of surgery is shorter compared with that for free flaps, it appears to be a good option for patients with severe anesthesiological risk factors. Therefore, the present study evaluated the functional and oncological outcomes of reconstructing defects after oropharyngeal carcinoma resection with a SMIF in these patients. A total of 10 patients underwent resection of lateral oropharyngeal carcinoma and ipsilateral neck dissection with closure of the defects using a SMIF. Oncological evaluation consisted of endoscopic and radiological standard-of-care restaging, while functional evaluation included a phoniatric swallowing examination with penetration-aspiration scale-score 6 months after surgery. All patients had T2 or T3 carcinoma, while 7 out of 10 patients had nodal involvement. Additionally, 7 out of 10 patients exhibited p16 expression. Pathological clear margins could be achieved in all patients. In all patients, no local, regional or distant recurrence occurred (median follow-up time, 26 months; range, 12-33 months). All patients had complete oral intake with their feeding tubes removed, with 1 patient restricted to dysphagia diet. Despite the severe comorbidities, there were no surgery-related or anesthesia-related complications. One patient who refused the recommended postoperative radiation developed enoral hair growth requiring regular trimming to avoid dysphagia. The SMIF is a reliable flap for reconstruction of lateral oropharyngeal defects with good oncological and functional outcomes. The reduced anesthesia duration appeared to be beneficial for patients with severe cardiac or pulmonary comorbidities. Male patients should be selected to undergo postoperative radiation to prevent enoral hair growth.
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