ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2026
Trends and risk factors of multidrug-resistant hospital-acquired infections in a Tunisian university hospital: repeated point prevalence surveys, 2023-2025.
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To assess temporal trends in hospital-acquired infections (HAIs) prevalence, antimicrobial resistance (AMR) patterns, and associated risk factors of multidrug resistance (MDR)-related HAI in a Tunisian hospital between 2023 and 2025. Design: Repeated point-prevalence surveys (PPSs). Setting: Sahloul University Hospital, Sousse, Tunisia. Patients: All patients hospitalized for more than 48 hours during each surveys. Methods: Data on HAI prevalence, isolated pathogens, and AMR profiles were collected through three PPSs conducted annually from 2023 to 2025. HAIs were defined according to the criteria of the Centers for Disease Control and Prevention. MDR was defined as nonsusceptibility to at least one agent in three or more antimicrobial classes. Results: From 2023 to 2025, 126 pathogens were responsible for 101 HAIs among 752 surveyed patients. The overall HAI prevalence was 10.9%, with no significant difference between the survey years (trend Conclusions: Repeated PPSs are an effective surveillance strategy for monitoring HAIs and AMR. These findings support the implementation of targeted antimicrobial stewardship and enhanced infection control interventions in Tunisian hospitals.
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