ReviewCureus2026
Effectiveness of Intra-oral Non-skeletally Anchored Appliances in the Correction of Skeletal Class III Malocclusion in Growing Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extra-oral appliances used for correcting skeletal Class III malocclusion are often bulky, unaesthetic, and heavily reliant on patient compliance, which can negatively affect treatment outcomes, particularly in growing patients. As a result, intra-oral alternatives have gained increasing attention due to their improved comfort, better acceptance, and reduced visibility. The objective of this systematic review was to examine and appraise existing evidence concerning the effectiveness of intra-oral, non-skeletally anchored appliances for correcting skeletal Class III malocclusion in growing individuals. A comprehensive and systematic search was conducted across five major electronic bibliographic databases, with no language restrictions, to ensure the broad inclusion of relevant studies. Only randomized controlled clinical trials (RCTs) assessing intra-oral non-skeletally anchored appliances were included in the review. A total of eight RCTs involving 336 growing patients met the inclusion criteria, although only two studies were suitable for quantitative meta-analysis. Among the evaluated appliances, the removable mandibular retractor (RMR) demonstrated forward movement of key skeletal landmarks, including point A (mean difference (MD) = 1.92 mm), point B (MD = 0.13 mm), prosthion (Pr) (MD = 1.97 mm), and infradental (Id) (MD = 0.16 mm). Additionally, RMR use was associated with a significant increase in the facial convexity angle (MD = 4.92°) and a reduction in the nasolabial angle (MD = 5.18°), indicating favorable soft tissue profile changes. The lower-clear-plate-based intermaxillary traction (LCP-IMT) appliance demonstrated the most significant improvement in sagittal skeletal relationship. It showed the greatest increase in the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.