Evidence map›Paper›PMID 42256811›Full record

ReviewOncology letters2026

Cancer stem cells and their molecular signaling mechanisms in tongue squamous cell carcinoma (Review).

Xuqiang Guo, Xuan Zhou, Wen Ran, Qiao Zhu, Wei Chen, Chengcheng Ma

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuqiang GuoDepartment of Stomatology, The First People's Hospital of Jingzhou and The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China.
Xuan ZhouDepartment of Stomatology, The First People's Hospital of Jingzhou and The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China.
Wen RanDepartment of Stomatology, The First People's Hospital of Jingzhou and The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China.
Qiao ZhuDepartment of Stomatology, The First People's Hospital of Jingzhou and The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China.
Wei ChenDepartment of Emergency Medicine, The First People's Hospital of Jingzhou and The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China.
Chengcheng MaDepartment of Otolaryngology, The First People's Hospital of Jingzhou and The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tongue squamous cell carcinoma (TSCC) remains a significant clinical challenge, owing to its high prevalence and poor prognosis. Cancer stem cells (CSCs) serve a critical role in driving the initiation and progression of TSCC. The present review examined the unique characteristics and functional dynamics of CSCs in TSCC, with particular emphasis on the molecular signaling pathways that regulate their behavior. Key pathways, including Wnt/β-catenin, Notch and Hedgehog signaling pathways, are explored to provide a comprehensive understanding of the mechanisms underlying TSCC. The present study was reported in accordance with the Preferred Reported Items for Systematic Reviews. Articles were sourced from PubMed (pubmed.ncbi.nlm.nih.gov/) using the search terms 'tongue squamous cell carcinoma', 'cancer stem cells', 'molecular signaling', 'Wnt/β-catenin', 'Notch', 'Hotch' and 'Hedgehog', covering the period from January 2001 to October 2025. The review was limited to papers published in English. A total of 437 studies was retrieved. Excluding those studies are not closely related to the topic, 138 were reviewed in detail for their originality and relevance to the broader scope of the present review. By mapping these key signaling networks, the present review aimed to provide a strong foundation for the development of precision therapeutic strategies targeting TSCC.

Indexed as

cancer stem cellsHhmolecular signalingNotchtongue squamous cell carcinomaWnt/β-catenin

Identifiers

PMID42256811
PMCPMC13237528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.