Evidence map›Paper›PMID 42256591›Full record

ArticleAddictive behaviors reports2026

Substance use stigma mechanisms associated with greater depressive symptoms, substance use-related problems, and lower behavioral activation.

Morgan S Anvari, Caroline A Sacko, Noah S Triplett, Valerie D Bradley, Mary B Kleinman, Abigail C Hines, Rithika Baskar, Jessica S Anane, Valerie A Earnshaw, Annabelle M Belcher and 1 more

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Article in Addictive behaviors reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Morgan S AnvariDepartment of Psychology, University of Maryland, College Park, MD, USA.
Caroline A SackoDepartment of Psychology, University of Maryland, College Park, MD, USA.
Noah S TriplettDepartment of Behavioral and Community Health, University of Maryland, College Park, MD, USA.
Valerie D BradleyDepartment of Psychology, University of Maryland, College Park, MD, USA.
Mary B KleinmanDepartment of Psychology, University of Maryland, College Park, MD, USA.
Abigail C HinesDepartment of Psychology, University of Maryland, College Park, MD, USA.
Rithika BaskarCenter for Substance Use, Addiction & Health Research (CESAR), University of Maryland, College Park, MD, USA.
Jessica S AnaneDepartment of Behavioral and Community Health, University of Maryland, College Park, MD, USA.
Valerie A EarnshawDepartment of Human Development & Family Sciences, University of Delaware, DE, USA.
Annabelle M BelcherDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Jessica F MagidsonDepartment of Psychology, University of Maryland, College Park, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Stigma is a well-recognized barrier to substance use (SU) treatment initiation and retention. It is theorized to operate through three distinct mechanisms: internalized, enacted, and anticipated. The unique associations between these specific stigma mechanisms and key psychosocial factors - such as engagement in reinforcing activities (i.e., behavioral activation), depression, and SU-related problems (e.g., social, financial) - remain unexplored, particularly among historically underserved populations. The current study examined how SU stigma in total and each mechanism is associated with these outcomes among individuals in an urban methadone clinic serving a historically underserved community. Method: This cross-sectional study utilized baseline data from a peer-delivered behavioral intervention trial to examine how SU stigma mechanisms are associated with behavioral activation (BA), depressive symptoms, and SU-related problems among a predominantly low-income sample in methadone treatment ( Results: Linear regression analyses revealed that overall SU stigma was associated with lower BA, higher depressive symptoms, and greater SU-related problems. In multiple linear regression models controlling for relevant covariates and stigma mechanisms, higher internalized SU stigma remained significantly associated with worse outcomes across all domains. Following multiple-testing correction, associations for anticipated stigma (with lower BA and higher depressive symptoms) and enacted stigma (with greater SU-related problems) were marginally significant. Conclusions: Findings highlight differential associations of stigma mechanisms in psychosocial functioning, and may point to a need to address internalized stigma in SU interventions. Future longitudinal research is needed to assess causal and mechanistic relationships between stigma, SU and psychosocial outcomes to inform targeted intervention development.

Indexed as

Behavioral activationDepressive symptomsPsychosocial functioningSubstance use-related problemsSubstance use stigma

Identifiers

PMID42256591
PMCPMC13234252

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.