ArticleFrontiers in neurology
The awakening effect of hyperbaric oxygen therapy combined with systematic auditory stimulation in comatose patients with craniocerebral injury and its influence on serum biomarkers.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Severe traumatic brain injury (sTBI) often results in prolonged coma and significant long-term disability. Evidence-based, widely accessible approaches to accelerate recovery of consciousness remain limited. This study evaluated whether adding a combined regimen of hyperbaric oxygen therapy (HBOT) and systematic auditory stimulation (SAS) to standard neurosurgical care improves recovery of consciousness and short-term outcomes in comatose patients with sTBI. Methods: In this prospective randomized controlled trial, 89 comatose patients with sTBI [Glasgow Coma Scale (GCS) < 8] were randomized to standard neurosurgical care (control, Results: Compared to the control group, the HBOT+SAS group demonstrated greater improvement in measures of consciousness at Day 28 (FOUR: 12.1 ± 2.4 vs. 9.3 ± 2.1; GCS: 11.3 ± 2.2 vs. 9.1 ± 1.9; CRS-R: 11.8 ± 2.3 vs. 8.1 ± 2.0; all Conclusion: The addition of HBOT+SAS to standard care was associated with improved recovery of consciousness and better 3-month functional outcomes in comatose patients with sTBI, supported by consistent findings from clinical scales and serum biomarkers. However, since the trial did not include HBOT-only or SAS-only comparator arms, the findings support the effectiveness of the combined regimen compared to standard care but do not determine whether HBOT and SAS have a synergistic effect.
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