Evidence map›Paper›PMID 42256545›Full record

ArticleHemaSphere2026

Clonal hematopoiesis dynamics influences long-term outcomes of follicular lymphoma: Results from FIL FOLL12 trial.

Nawar Maher, Riccardo Moia, Mohammad Almasri, Luca Cividini, Elisa Genuardi, Chiara Cosentino, Roberta Soscia, Giovanni Manfredi Assanto, Rita Tavarozzi, Maria Carmela Vegliante and 31 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Nawar MaherDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Riccardo MoiaDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.ORCID https://orcid.org/0000-0001-7393-1138
Mohammad AlmasriDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Luca CividiniDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Elisa GenuardiDivision of Hematology, Department of Molecular Biotechnologies and Health Sciences University of Torino Torino Italy.
Chiara CosentinoDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Roberta SosciaHematology, Department of Translational and Precision Medicine Sapienza University of Rome - AOU Policlinico Umberto I Roma Italy.
Giovanni Manfredi AssantoHematology, Department of Translational and Precision Medicine Sapienza University of Rome - AOU Policlinico Umberto I Roma Italy.ORCID https://orcid.org/0000-0002-6190-9635
Rita TavarozziDepartment of Translational Medicine, SCDU Ematologia AO SS Antonio e Biagio E Cesare Arrigo Università del Piemonte Orientale Alessandria Italy.
Maria Carmela VeglianteHematology and Cell Therapy Unit IRCCS Istituto Tumori 'Giovanni Paolo II Bari Italy.
Luisa LorenziPathology Unit, Department of Molecular and Translational Medicine University of Brescia Brescia Italy.
Annalisa AndornoDivision of Pathology, Department of Health Sciences Università del Piemonte Orientale and Ospedale Maggiore della Carità Novara Italy.
Luca ArcainiDepartment of Molecular Medicine University of Pavia & Division of Hematology, Fondazione IRCCS Policlinico San Matteo Pavia Italy.ORCID https://orcid.org/0000-0002-9504-991X
Simone RagainiDivision of Hematology, Department of Molecular Biotechnologies and Health Sciences University of Torino Torino Italy.ORCID https://orcid.org/0000-0003-3899-5755
Benedetta PucciniHematology Unit Careggi University Hospital Firenze Italy.
Caterina PattiOspedali Riuniti Villa Sofia - Cervello (Presidio V. Cervello) Palermo Italy.
Armando SantoroDepartment of Oncology and Haematology IRCCS Humanitas Research Hospital Rozzano Italy.
Gloria Margiotta-CasaluciDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Vittorio Ruggero ZilioliDivision of Hematology ASST Grande Ospedale Metropolitano Niguarda Milano Italy.ORCID https://orcid.org/0000-0001-6915-2246
Manuela ZanniDepartment of Translational Medicine, SCDU Ematologia AO SS Antonio e Biagio E Cesare Arrigo Università del Piemonte Orientale Alessandria Italy.
Sonia RonconiIRCCS Istituto Romagnolo per lo studio dei Tumori "Dino Amadori" - IRST S.R.L, Ematologia Meldola Italy.
Francesco Di RaimondoAzienda Ospedaliera Universitaria Policlinico - S. Marco, UOC di Ematologia & University of Catania Catania Italy.
Annalisa ArcariAzienda USL Piacenza, UOC Ematologia e Centro Trapianti Piacenza Italy.
Catello CalifanoPresidio ospedaliero "A. TORTORA", U.O. Onco-ematologia Pagani Italy.
Claudia CastellinoA.O. S. Croce e Carle, S.C. Ematologia Cuneo Italy.
Annarita ConconiAzienda Sanitaria Locale, Ematologia, Ospedale degli Infermi Biella Italy.
Tommasina PerroneAOU Policlinico Consorziale, U.O. Ematologia con Trapianto Bari Italy.
Donato ManninaAzienda Ospedali Riuniti Papardo-Piemonte, S.C. Ematologia Messina Italy.
Caterina PlentedaAOU di Parma, UOC Ematologia e CTMO Parma Italy.
Francesco AlesianiASUR 8, Medicina Interna e Ematologia, Civitanova Marche Italy.
Francesca Gaia RossiOspedale Maggiore Policlinico - Fondazione IRCCS Ca Granda, Ematologia Milano Italy.
Angelo Michele CarellaEmatologia e Unità Terapia Intensiva Ematologica, IRCCS Fondazione Casa Sollievo della Sofferenza San Giovanni Rotondo (FG) San Giovanni Rotondo Italy.
Luigi MarcheselliUffici Studi Fondazione Italiana Linfomi Modena Italy.
Sara GalimbertiHematology Division Pisa University Hospital, Department of Clinical and Experimental Medicine, University of Pisa Pisa Italy.
Sabino CiavarellaHematology and Cell Therapy Unit IRCCS Istituto Tumori 'Giovanni Paolo II Bari Italy.
Riccardo BombenCentro di Riferimento Oncologico di Aviano Aviano Italy.ORCID https://orcid.org/0000-0002-8746-9404
Ilaria Del GiudiceHematology, Department of Translational and Precision Medicine Sapienza University of Rome - AOU Policlinico Umberto I Roma Italy.
Marco LadettoDepartment of Translational Medicine, SCDU Ematologia AO SS Antonio e Biagio E Cesare Arrigo Università del Piemonte Orientale Alessandria Italy.
Gianluca GaidanoDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Stefano LuminariEmatologia, Azienda Unità Sanitaria Locale - IRCCS Reggio Emilia Reggio Emilia Italy.ORCID https://orcid.org/0000-0001-8446-2285
Simone FerreroDivision of Hematology, Department of Molecular Biotechnologies and Health Sciences University of Torino Torino Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whether clonal hematopoiesis (CH) in follicular lymphoma (FL) patients affects clinical outcome or is merely a bystander phenomenon is unclear. We leveraged the Phase III Fondazione Italiana Linfomi FOLL12 trial, which treated patients with advanced-stage FL with R-CHOP or R-Bendamustine, to evaluate the role of myeloid CH at baseline and after chemoimmunotherapy (CIT). A total of 528 serial blood samples from 242 FL were analyzed by CAPP-Seq. At baseline, CH occurred in 35.5% patients with

Identifiers

PMID42256545
PMCPMC13240525

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.