ArticleLeukemia research reports2026
Treatment outcomes of acute leukemia during pregnancy at the National Institute of Hematology and Blood Transfusion.
Article in Leukemia research reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Managing acute leukemia during pregnancy poses clinical challenges requiring a balance between maternal treatment and fetal preservation. From 2019 to 2024, 22 pregnant women were diagnosed with acute leukemia, including 7 acute lymphoblastic leukemia, 15 cases of acute myeloid leukemia, of which 1 was acute promyelocytic leukemia. Diagnosis occurred in the first, second, and third trimesters in 5, 10, and 7 patients, respectively. Nine patients elected pregnancy termination, one had a spontaneous abortion, one had intrauterine fetal demise, and three experienced concurrent maternal and fetal death. Eight patients delivered via elective cesarean section, including one twin pregnancy, resulting in 9 live births. Four neonates (including one twin pregnancy) were exposed to in utero chemotherapy, with no observed congenital anomalies. Chemotherapy was administered to 11 patients, including 3 during pregnancy, all achieving temporary disease control. These findings provide real-world data to inform the management of acute leukemia during pregnancy.
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