Observational studyJournal of preventive medicine and hygiene2025
Health-related quality of life of patients with chronic kidney disease: Does it improve after initiation of haemodialysis? A single-centre study from South India.
Observational study in Journal of preventive medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: In recent years, research on quality of life has emerged as a valuable tool in assessing the effectiveness of therapeutic interventions in chronic kidney disease. This study aims to assess the health-related quality of life among patients with chronic kidney disease, and draw comparisons between haemodialysis and non-dialysis patients. Methods: This is a prospective questionnaire-based observational study involving 148 patients (81 haemodialysis and 67 non-dialysis patients) with chronic kidney disease (Stage 3-5D) conducted in a tertiary care hospital in South India over six months (July 2023-December 2023). The instrument used was the Kidney Disease Quality of Life Short Form-36. Results: The overall mean health-related quality of life score was better among non-dialysis patients compared to haemodialysis patients. A reduction in various domains, including physical functioning (p < 0.014), role limitations due to physical health (p < 0.001), role limitations due to emotional problems (p < 0.001) and social functioning (p < 0.007) were observed in the haemodialysis group. In our population, age, gender, employment status and socioeconomic classes were found to be independent predictors of health-related quality of life. Conclusion: This study highlights the deleterious impact of chronic kidney disease on health-related quality of life, with more significant deterioration among patients undergoing haemodialysis compared to non-dialysis patients. Further, this study advocates potential areas of target for therapeutic intervention.
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