ReviewJournal of clinical and translational science2026
Evolving roles of Data Coordinating Centers in multisite research: Challenges and adaptations from a rapid scoping review.
Review in Journal of clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data Coordinating Centers (DCCs) play essential roles in multisite clinical and translational research, ensuring consistent protocol implementation, data integrity, and regulatory compliance across geographically and organizationally diverse sites. As study design, regulatory, and technological complexity have evolved, DCC responsibilities have expanded beyond data coordination. This rapid scoping review maps published experiences from academic DCCs to address two questions: (i) What key organizational and operational challenges have been reported? (ii) What solutions and emerging technologies have been adopted in response? We conducted a rapid scoping review in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). We searched the peer-reviewed literature (2010-2025) using PubMed, Scopus, and the Web of Science Core Collection. Fifteen reports describing 16 DCCs were included in this review. DCCs faced recurring challenges related to infrastructure development, multisite coordination, regulatory governance, data heterogeneity, and workforce development. Reported adaptations include homegrown modular infrastructure solutions, standardized workflows, streamlined proactive regulatory processes, and workforce investments. By synthesizing evidence on DCC challenges and adaptations, this review provides practical guidance to help DCCs enhance operational feasibility and uphold scientific integrity in multisite clinical and translational research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.