ArticleCase reports in psychiatry2026
A 24-Year-Old Male Adult With a Severe Intellectual Developmental Disorder and Intractable Challenging Behaviors: A Case Report.
Article in Case reports in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A 24-Year-Old Male Adult With a Severe Intellectual Developmental Disorder and Intractable Challenging Behaviors: A Case Report.Case reports in psychiatry · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This case highlights the clinical complexity of caring for individuals with autism spectrum disorder (ASD) and severe intellectual developmental disorder (IDD), particularly in the context of prolonged mechanical restraint, psychotropic polypharmacy, and life-threatening somatic complications. It illustrates how a multidisciplinary and individualized neurobehavioral approach can lead to major clinical improvement despite an initially poor prognosis and limitations regarding intensive care. Case Presentation: Nathan is a 24-year-old man of Slavic origin with ASD and severe IDD who had been subjected to continuous mechanical restraint for 2 years and was receiving five concomitant antipsychotic medications. He presented with severe behavioral dysregulation in a context of chronic anxiety, marked communication limitations, recurrent aspiration pneumonia related to gastrostomy feeding, and adverse effects associated with antipsychotic treatment. He was referred to a specialized neurobehavioral unit, where a multidisciplinary team-including psychiatry, intensive care, palliative care, and ethics specialists-agreed on a conservative management plan. Antipsychotic treatment was streamlined to clozapine, fluoxetine was later introduced, and care combined nutritional rehabilitation, communication-focused support, and individualized psychoeducational, occupational, and psychomotor interventions in a highly structured environment. Oral feeding was gradually reintroduced, ultimately allowing gastrostomy removal, and restrictive measures were progressively discontinued. Overtime, his behavioral symptoms, emotional regulation, physical health, mobility, and overall quality of life improved markedly. Conclusions: This case underscores the importance of integrated multidisciplinary care in complex ASD/IDD presentations involving severe behavioral and somatic complications. Psychopharmacological simplification, environmental and communication adaptations, and individualized rehabilitation strategies were central to the improvement in both somatic outcomes and behavioral functioning. It also highlights the need to recognize prolonged mechanical restraint as a harmful and unsustainable management strategy in individuals with severe neurodevelopmental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.