ReviewRSC chemical biology2026
Understanding insulin-like peptide 5 (INSL5) and relaxin family peptide receptor 4 (RXFP4): structure, signalling, and function.
Hongkang Wu, Huahao Wang, Isabelle Riches, Ivan Maslov, Predrag Kalaba, Myat Noe Han, Ruslan Pustovit, John B Furness, Ross A D Bathgate, Mohammed Akhter Hossain
Abstract readReview
In one paragraphReview in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Hongkang WuFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.
Huahao WangFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.
Isabelle RichesFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.
Ivan MaslovFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.
Predrag KalabaFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.
Myat Noe HanFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.ORCID https://orcid.org/0000-0003-3028-7359 Ruslan PustovitFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.
John B FurnessFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.ORCID https://orcid.org/0000-0002-0219-3438 Ross A D BathgateFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.
Mohammed Akhter HossainFlorey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health, The University of Melbourne Parkville Victoria 3052 Australia akhter.hossain@unimelb.edu.au.ORCID https://orcid.org/0000-0002-9961-0006 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Insulin-like peptide 5 (INSL5) is a member of the relaxin/insulin peptide family, predominantly produced by enteroendocrine L cells in the distal gut. Although initially characterised based on its structural similarity to insulin and relaxin peptides, INSL5 is now increasingly recognised as an important regulator of gastrointestinal physiology. Its endogenous receptor, relaxin family peptide receptor 4 (RXFP4), is primarily expressed in the gastrointestinal tract and signals mainly through G
Identifiers
PMID42256349
PMCPMC13234771
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