Evidence map›Paper›PMID 42256345›Full record

ArticleFood chemistry. Molecular sciences2026

Proteomic responses to the effect of coprophagy prevention on meat quality in New Zealand white rabbits.

Hui He, Zhitong Wang, Zhichao Li, Mengke Ni, Mengjuan Chen, Chaohui Guo, Yaping Wang, Hanfang Cai, Ming Li, Huifen Xu

Abstract read
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Article in Food chemistry. Molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Hui HeCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.
Zhitong WangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.
Zhichao LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.
Mengke NiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.
Mengjuan ChenCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.
Chaohui GuoCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.
Yaping WangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.
Hanfang CaiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.
Ming LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.
Huifen XuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coprophagy is an innate behavior of rabbits, and rabbit meat is favored by consumers for its distinctive nutritional characteristics. However, the relationship between coprophagy and meat quality in rabbits remains unclear. Therefore, this study investigated the effects of coprophagy prevention on growth performance and meat quality using a coprophagy-prevention model. The results showed that coprophagy prevention reduced growth performance and several meat quality parameters while increasing muscle fiber density. In addition, coprophagy prevention altered the nutritional composition of skeletal muscle by reducing unsaturated fatty acids (UFAs) and essential amino acids (EAAs), while increasing total lipid content and the proportion of saturated fatty acids (SFAs). Tandem mass tag (TMT)-based quantitative proteomic analysis identified 267 differentially expressed proteins (DEPs) in skeletal muscle following coprophagy prevention, which were mainly enriched in pathways related to muscle development, energy metabolism, fatty acid transport, and lipid metabolism. Further analyses suggested that alterations in lipid deposition and fatty acid composition may be associated with changes in mitochondrial oxidative phosphorylation and ATP production; however, these mechanistic relationships require further validation. Although several cognition-related pathways and reduced serum dopamine (DA) and 5-hydroxytryptamine (5-HT) levels were observed, the functional significance of these findings remains unclear due to the lack of behavioural assessments. Overall, the present study suggests that coprophagy prevention is associated with impaired growth performance and altered meat quality in rabbits. These findings provide preliminary insights into the potential metabolic changes associated with coprophagy prevention and highlight the biological importance of coprophagy in rabbit production.

Indexed as

Coprophagy preventionFatty acidsGrowth performanceOxidative phosphorylationProteomics

Identifiers

PMID42256345
PMCPMC13234256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.