LIF and Oncostatin M mitigate LPS-induced acute endometritis via distinct immunoregulatory mechanisms in peritoneal macrophages

Marion Ravelojaona, Julie Girouard, Cathy Vaillancourt, Céline Van Themsche, Carlos Reyes-Moreno

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marion RavelojaonaDépartement de Biologie Médicale, Université du Québec à Trois-Rivières, 3351 Boul. des Forges, Trois-Rivières, QC G8Z 4M3, Canada.

Julie GirouardDépartement de Biologie Médicale, Université du Québec à Trois-Rivières, 3351 Boul. des Forges, Trois-Rivières, QC G8Z 4M3, Canada.

Cathy VaillancourtCentre de Recherche Interuniversitaire en Reproduction et Développement-Réseau Québécois en Reproduction (CIRD-RQR), Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.

Céline Van ThemscheDépartement de Biologie Médicale, Université du Québec à Trois-Rivières, 3351 Boul. des Forges, Trois-Rivières, QC G8Z 4M3, Canada.

Carlos Reyes-MorenoDépartement de Biologie Médicale, Université du Québec à Trois-Rivières, 3351 Boul. des Forges, Trois-Rivières, QC G8Z 4M3, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute endometritis, often triggered by Gram-negative bacterial endotoxins such as lipopolysaccharide (LPS), disrupts endometrial integrity, induces robust pro-inflammatory macrophage activation, and compromises uterine function, potentially leading to infertility and adverse pregnancy outcomes. Here, we demonstrate that IL-6 family cytokines, Leukemia Inhibitory Factor (LIF) and Oncostatin M (OSM), exert complementary yet distinct immunoregulatory effects that mitigate LPS-induced acute endometritis

Indexed as

CancerImmunologyMicroenvironment

Identifiers

PMID42256298

DOI10.1016/j.isci.2026.116046

PMCPMC13235486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.