Evidence map›Paper›PMID 42256279›Full record

ArticleiScience2026

KPT-330 alleviates osteoarthritis by inhibiting subchondral bone osteoclastogenesis via the NF-κB and MAPK signaling pathways.

Wugui Chen, Yijie Liang, Chengzhao Liu, Guangfeng Ling, Shiqing Lei, Jiaqing Huang, Wang Lin, Chengshou Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wugui ChenDepartment of Orthopedics, Mindong Hospital Affiliated Fujian Medical University, Fujian, China.
Yijie LiangDepartment of Orthopedics, Zhangzhou Hospital Affiliated Fujian Medical University, Zhangzhou, China.
Chengzhao LiuDepartment of Orthopedics, Mindong Hospital Affiliated Fujian Medical University, Fujian, China.
Guangfeng LingDepartment of Orthopedics, Mindong Hospital Affiliated Fujian Medical University, Fujian, China.
Shiqing LeiDepartment of Orthopedics, Mindong Hospital Affiliated Fujian Medical University, Fujian, China.
Jiaqing HuangDepartment of Orthopedics, Mindong Hospital Affiliated Fujian Medical University, Fujian, China.
Wang LinDepartment of Orthopedics, Mindong Hospital Affiliated Fujian Medical University, Fujian, China.
Chengshou LinDepartment of Orthopedics, Mindong Hospital Affiliated Fujian Medical University, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoclast-driven subchondral bone remodeling is a critical driver of osteoarthritis (OA) progression. While exportin-1 (XPO1) inhibitors demonstrate anti-osteoclastogenic potential in cancers, their therapeutic utility in OA remains unexplored. We hypothesized that selective XPO1 inhibition by KPT-330 suppresses osteoclastogenesis to ameliorate OA. In destabilization of the medial meniscus (DMM)-induced OA mice, KPT-330 reversed subchondral bone loss, preserved cartilage integrity, and reduced osteoclast numbers.

Indexed as

BiochemistryBiological sciencesHealth sciencesMolecular biology

Identifiers

PMID42256279
PMCPMC13233564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.