Evidence map›Paper›PMID 42256244›Full record

ArticleJHLT open2026

Aspirin therapy after heart transplantation is associated with higher myocardial perfusion reserve assessed by cardiovascular magnetic resonance imaging.

R Jablonowski, I H Löfman, H B Andersson, G Gjesdal, C Fogarasi, P Kellman, M Melin, H Engblom, H Arheden, M Carlsson and 2 more

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In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

R JablonowskiClinical Physiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.
I H LöfmanDepartment of Medicine, Karolinska Institute, Solna, Stockholm, Sweden.
H B AnderssonCardiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.
G GjesdalCardiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.
C FogarasiDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
P KellmanNational Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, MD.
M MelinDepartment of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
H EngblomClinical Physiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.
H ArhedenClinical Physiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.
M CarlssonDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
J NickanderDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
O Ö BraunCardiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiac allograft vasculopathy (CAV) is one of the major long-term complications in patients after heart transplantation (HTx) limiting allograft function and longevity. CAV can be studied non-invasively by evaluating myocardial perfusion (MP). Aspirin is re--ed after Htx, but it is unclear whether it affects the development of CAV. The aim of this study was to investigate the association between aspirin therapy and MP, as a marker of CAV, using cardiovascular magnetic resonance (CMR). Methods: We consecutively included HTx patients from 2 centers in Sweden who were examined with CMR and coronary angiography. Patients were categorized by the presence or absence of aspirin therapy. As a part of routine surveillance, quantitative short-axis perfusion maps were acquired at rest and during stress hyperemia. A global average MP was calculated at rest and stress and myocardial perfusion reserve (MPR) was defined as the ratio between stress and rest MP. Cine images and T1 maps were also acquired. Results: A total of 137 patients ( Conclusion: In this retrospective study, aspirin therapy in heart transplant patients was independently associated with higher myocardial perfusion reserve.

Indexed as

AspirinCardiac allograft vasculopathyCardiovascular magnetic resonanceHeart transplantMyocardial perfusion

Identifiers

PMID42256244
PMCPMC13240781

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.