ArticleHRB open research2026
The Management of Acne in General Practice using Isotretinoin: A Scoping Review Protocol.
Article in HRB open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Acne Vulgaris (Acne) is a common, chronic, cutaneous disorder associated with scarring, hyperpigmentation, and adverse psychological effects. The high prevalence of acne places a significant burden on healthcare systems worldwide due to the cost of treatment. The high usage of antibiotics in the treatment of this condition also has a significant impact on the prevalence of antimicrobial resistance. Isotretinoin is considered to be the most effective treatment for the management of severe acne; however, issues remain with inequitable access to this drug. General Practitioners (GPs) are ideally placed to identify and manage patients with moderate-to-severe acne; however, in many countries the prescription of isotretinoin is limited to secondary care. To the authors' knowledge, no review has been conducted to identify, map and analyse literature pertaining to GPs' use of isotretinoin for the management of acne. Methods: As recommended by the Joanna Briggs Institute (JBI), a three-step search strategy will be utilised for this scoping review. A search strategy will be developed using key words, search terms and controlled vocabulary suitable for each literature source. Both primary and grey literature will be eligible for inclusion in this review. Identified literature will be screened by two reviewers to identify relevant evidence. The full-text sources will then be evaluated by two independent researchers to extract relevant data. The findings of this review will be reported as a descriptive summary accompanied by a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram. Results: This scoping review protocol outlines a systematic approach to map a broad range of sources and summarise existing evidence regarding GPs' use of isotretinoin for the management of acne in primary care. Conclusions: The objective of this scoping review is to comprehensively identify, map, and analyse literature pertaining to the management of acne using isotretinoin in general practice. Review registration: Registered on Open Science Framework on 02/10/2025 ( https://osf.io/rak3d/).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.