ArticleFrontiers in cellular and infection microbiology2026
Molecular epidemiology and clinical profiles of carbapenem-resistant Enterobacterales in neonates from two large children's hospitals in southwestern China.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Carbapenem-resistant Enterobacterales (CRE) are a global health threat due to their high antimicrobial resistance and transmissibility. However, data on CRE infection in neonates in China are lacking. We collected non-duplicate CRE isolates from neonates between 2018 and 2022 in Chongqing and Kunming and investigated their antimicrobial resistance profiles, risk factors, and molecular epidemiology. Methods: Antimicrobial susceptibility testing was performed using broth microdilution. Polymerase chain reaction (PCR) was performed to detect carbapenem-resistance genes, extended-spectrum β-lactamase (ESBL) genes, and virulence genes. Multilocus sequence typing (MLST) was used to analyze strain relatedness. Clinical data were collected and multivariable logistic regression analysis was used to identify risk factors. Results: A total of 139 non-duplicate neonatal CRE isolates were collected from 2018 to 2022, comprising carbapenem-resistant Conclusion: NDM is highly prevalent and transferable among CRE isolates in neonatal infections. The high-risk ST2407 NDM-producing
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