SynthesisFrontiers in cellular and infection microbiology2026
Trends and hotspots in gut microbiota and neonatal necrotizing enterocolitis: a bibliometric analysis.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research trends in cytokine regulation of immunotherapy in non-small cell lung cancer: a bibliometric and BERTopic analysis from 2015 to 2025.Journal of thoracic disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neonatal necrotizing enterocolitis (NEC) is one of the most life-threatening gastrointestinal emergencies in preterm infants. Accumulating evidence has identified gut microbiota dysbiosis as a key driver of NEC pathogenesis. Probiotics/prebiotics and bioactive components in breast milk can reduce NEC risk by modulating microbiota balance. With microbial intervention strategies becoming a research hotspot, publications in this field have surged over the past 5 years. However, no studies have yet systematically mapped its knowledge evolution and collaboration networks. Objective: This study pioneers the use of bibliometric methods to systematically analyze global research trends, core contributors (countries, institutions, authors), and emerging frontiers in gut microbiota and NEC research from 2005 to 2024, aiming to provide strategic guidance for future translational studies. Methods: A total of 1,011 English-language articles were screened from the Web of Science Core Collection. Software tools, including VOSviewer, CiteSpace, and Pajek, were employed to analyze publication trends, country/region and institution collaboration networks, journal co-citations, keyword clustering, and keyword bursts. Results: Annual publications increased from 5 in 2005 to a peak of 120 in 2023, with cumulative citations reaching 52,330 and an h-index of 115. The United States led in output (424 publications, 41.9%) and total citations (30,446). China ranked second in publications (158 articles) but exhibited lower average citations per article (22.65). The University of California System (65 publications) and the State University System of Florida (51 publications) were the most productive institutions. Mark A. Underwood (31 publications) focused on multi-omics mechanisms, while Josef Neu achieved the highest average citations per article (107.88) for his work on microbe-host interactions. "Nutrients" published the most articles (49), while "Microbiome" (impact factor 12.7) demonstrated the highest influence. Research hotspots evolved from early-stage microbiota composition analysis to mid-phase mechanism exploration and probiotic intervention evidence synthesis, shifting recently toward clinical translation, intestinal barrier repair, and stem cell therapy. Conclusion: Research on gut microbiota and NEC shows sustained growth, with trends shifting from microbiota structure description to multi-omics mechanistic exploration and accelerating clinical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.