ArticleFrontiers in cellular and infection microbiology2026
Clinical application of synovial fluid albumin-to-globulin ratio as a novel biomarker in diagnosing chronic periprosthetic joint infection.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Periprosthetic joint infection (PJI) is one of the most common and severe complications following joint arthroplasty. Early diagnosis is essential for timely and effective clinical intervention and carries great clinical significance. This study aims to evaluate the value of the albumin-to-globulin ratio (AGR) in synovial fluid (SF) for diagnosing PJI and compare its diagnostic performance with traditional biomarkers such as serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), synovial fluid polymorphonuclear percentage (SF-PMN%), and the potential marker serum albumin-to-globulin ratio (SE-AGR). Methods: This prospective study enrolled 230 patients who experienced pain following total hip or total knee arthroplasty, including 97 cases of PJI and 133 cases of aseptic failure(AF). Blood samples and synovial fluid aspirates were collected within 24 hours preoperatively. The association between each variable and PJI was evaluated using univariate logistic regression analysis, and the diagnostic performance of each indicator was assessed through receiver operating characteristic (ROC) curve analysis. Results: The results of the study showed that the Wald χ Conclusion: SF-AGR shows promise as a novel biomarker for the diagnosis of PJI, supporting its potential use as an adjunct to current diagnostic approaches. Diagnosis, Periprosthetic Joint Infection, Albumin-to-Globulin Ratio, Synovial Fluid Biomarkers, Revision arthroplasty.
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