Transient blood-brain barrier opening by focused ultrasound enhances ferumoxytol accumulation in glioblastoma.

Giovanni M Saladino, Payton J Martinez, Jie Wang, Raheleh Roudi, Giacomo Annio, Raag D Airan, Heike E Daldrup-Link

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Giovanni M SaladinoDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.

Payton J MartinezDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.

Jie WangDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.

Raheleh RoudiDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.

Giacomo AnnioDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.

Raag D AiranDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.

Heike E Daldrup-LinkDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoparticle delivery to glioblastoma is limited by the blood-brain barrier (BBB), which restricts the transport of diagnostic and therapeutic agents into tumor tissue. Microbubble-mediated focused ultrasound (FUS) can transiently increase BBB permeability and enhance localized delivery of molecular probes and drugs. We tested whether MRI-guided microbubble-assisted FUS at 650 kHz enables spatially controlled and quantitatively measurable delivery of the FDA-approved ferumoxytol (FMX), an iron oxide nanoparticle formulation. Acoustic simulations were employed to quantify transcranial pressure fields and assess pressure-dependent BBB opening at a clinically relevant frequency and were experimentally validated in healthy mice. In mice bearing orthotopic U87 glioblastoma, MRI-guided microbubble-assisted FUS was focally applied to the tumor region, with intravenously administered Definity microbubbles mediating transient BBB opening, followed by intravenous injection of fluorescein-labeled FMX. Nanoparticle accumulation was quantified using

Indexed as

Brain tumor barrier modulationFerumoxytol deliveryGlioblastomaMagnetic resonance imagingMicrobubble-mediated focused ultrasound

Identifiers

PMID42256082

DOI10.1016/j.mtbio.2026.103280

PMCPMC13242036

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