ArticleMaterials today. Bio2026
Leveraging antisolvent-processed β-sitosterol to construct a multifunctional curcumin-loaded oleogel for diabetic wound healing.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
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8 authors.
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Abstract
The complex microenvironment of diabetic wounds is the primary cause of slow wound healing, manifesting as a vicious cycle of excessive reactive oxygen species (ROS) accumulation and overexpression of inflammatory factors. Regulating this microenvironment by inhibiting wound inflammation, oxidative stress, and bacterial infection is a key challenge in the treatment of diabetic wounds. In this study, β-sitosterol particles (AS-Sit) were obtained via anti-solvent precipitation which solved the problem of poor dispersibility of β-sitosterol and combined them with candelilla wax to develop a novel multifunctional oleogel system capable of loading curcumin. The oleogel system demonstrates notable stability, spreadability, and sustained-release performance. Furthermore, the synergistic effects of β-sitosterol and curcumin resulted in the OG/Cur-0.15% oleogel demonstrating significant efficacy in bacterial elimination, ROS scavenging, fibroblast migration promotion, macrophage M
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