Magnetic hydrogel-mediated periodic stimulation enhances mesenchymal stem cell small extracellular vesicle release.

Chen Wang, Ye Chen, Tianhao Yan, Shuxin Zhang, Xiaoru Li, Shangquan Wu, Qingchuan Zhang

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chen WangCAS Key Laboratory of Mechanical Behavior and Design of Material, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230027, China.

Ye ChenCAS Key Laboratory of Mechanical Behavior and Design of Material, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230027, China.

Tianhao YanCollege of Basic Medical Sciences, Jilin University, Changchun, 130021, China.

Shuxin ZhangCAS Key Laboratory of Mechanical Behavior and Design of Material, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230027, China.

Xiaoru LiCAS Key Laboratory of Mechanical Behavior and Design of Material, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230027, China.

Shangquan WuCAS Key Laboratory of Mechanical Behavior and Design of Material, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230027, China.

Qingchuan ZhangCAS Key Laboratory of Mechanical Behavior and Design of Material, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230027, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) are regarded as important "cell-free" therapeutic carriers due to their potential for immune regulation and tissue repair. However, their large-scale application is constrained by bottlenecks such as low secretion yields under conventional culture conditions. This study established a magnetically controlled dynamic mechanical stimulation platform to enhance MSC-sEVs production. Superparamagnetic Fe

Indexed as

Dynamic mechanical loadingMagnetic hydrogelsSmall extracellular vesicle

Identifiers

PMID42256076

DOI10.1016/j.mtbio.2026.103285

PMCPMC13241665

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.