ArticleJournal of pain research2026
Association of Liposomal Bupivacaine with Postoperative Pain, Opioid Consumption and Early Functional Exercise in Tibial Plateau Fracture: A Retrospective Cohort Study.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To investigate the association of local infiltration with liposomal bupivacaine (LB) on postoperative pain, opioid consumption, and early functional recovery in patients undergoing open reduction and internal fixation (ORIF) for tibial plateau fracture. Patients and Methods: A retrospective cohort study was conducted including 252 patients aged 18-80 years treated between 2022 and 2024. Patients were divided into LB group (n=142) and non-LB group (n=110). Primary outcomes were resting visual analogue scale (VAS) pain scores at 24, 48, and 72 hours postoperatively and total opioid consumption. Secondary outcomes included time to first opioid use, time to first functional exercise, length of hospital stay, and adverse events. Normal distribution was tested using the Shapiro-Wilk test. Continuous variables were compared using independent Results: The LB group showed significantly lower resting VAS scores at 24, 48, and 72 hours, lower total and time-dependent opioid consumption, delayed time to first opioid use, earlier initial functional exercise, and shorter hospital stay (all P<0.05). No significant intergroup differences were observed in non-opioid analgesic use, adverse events, PCA application, fracture healing time, or final Hospital for Special Surgery (HSS) knee scores (all P>0.05). Conclusion: In this retrospective cohort study, perioperative local infiltration with LB was associated with reduced postoperative pain, lower opioid consumption, earlier functional exercise, and shorter hospital stay among patients undergoing ORIF for tibial plateau fracture, with a favorable safety profile. LB may be considered a valuable component of multimodal analgesia in this clinical setting.
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