ArticleOphthalmology science2026
A Primary Open-Angle Glaucoma Locus Near Transcription Factor
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Funding
Abstract
Objective: To identify genetic risk variants for primary open-angle glaucoma (POAG) and prioritize biologically relevant genes through integration of genetic association, regulatory annotation, ocular transcriptomics, and functional modeling. Design: A case-control genome-wide association study (GWAS) with integrative functional follow-up. Participants: A total of 234 153 United States Veterans of European ancestry enrolled in the Million Veteran Program, including 10 738 POAG cases and 223 415 controls. Methods: We conducted a POAG GWAS using electronic health record-based phenotyping and logistic regression adjusted for age, sex, and genetic ancestry. Genome-wide significant loci were evaluated using statistical fine-mapping and colocalization with expression and splicing quantitative trait loci across ocular and nonocular tissues. Bulk and single-cell transcriptomic datasets were interrogated to assess gene expression in glaucoma-relevant tissues and cell types. Functional relevance was evaluated by examining gene expression responses to cyclic mechanical stretch (CMS) with and without transforming growth factor beta 2 (TGFβ2) in primary human trabecular meshwork (HTM) cells. Ortholog expression was assessed in zebrafish. Main Outcome Measures: Genome-wide significant variant associations with POAG, colocalized regulatory signals, ocular tissue and cell-type expression patterns, and differential gene expression under biomechanical and profibrotic stress conditions. Results: Genome-wide association study identified a significant association near Conclusions: Integration of GWAS, regulatory annotation, ocular transcriptomics, and functional modeling prioritizes Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.