ArticleOphthalmology science2026
Hemispheric Asymmetry of Outer Retinal Structure and Function in Retinitis Pigmentosa.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Objective: To investigate vertical hemispheric asymmetry of the outer retinal structure using structural and functional parameters in patients with retinitis pigmentosa (RP) and assess its association with genotype and age. Design: A retrospective observational study. Participants: We analyzed 928 eyes from 496 patients with advanced RP at a single tertiary center. Methods: We measured hemispheric asymmetry of the outer retinal structure using a fully automated deep learning pipeline for segmenting the ellipsoid zone (EZ) from volume scan images obtained by spectral-domain OCT. Additionally, we evaluated the visual field asymmetry with a custom algorithm to quantify field angles assessed using Goldmann perimetry across 24 meridians. We assessed hemispheric asymmetries using linear mixed-effects models and performed subgroup analyses to determine whether the asymmetry was associated with genotype and age. Further, we modeled longitudinal changes in EZ area using exponential decline. Main Outcome Measures: Superior and inferior hemispheric preservation of the EZ area (mm Results: At the initial presentation, the superior EZ area was significantly larger than the inferior area (3.47 ± 0.11 mm Conclusions: Patients with RP consistently exhibited vertical hemispheric asymmetry of the outer retinal structure, with superior dominant structural and inferior dominant visual field preservation. This spatially polarized pattern represents a novel characteristic of RP and provides new insights into the regional vulnerability of photoreceptors. Financial Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article.
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