ArticleBrain communications2026
Tau topography subtypes account for clinical heterogeneity and longitudinal trajectories in early-onset Alzheimer's disease.
Abstract read
In one paragraph
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Atypical Alzheimer disease: a multi-axis framework toward defining heterogeneity.Nature reviews. Neurology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors.
Marlene LinEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Konstantinos ChiotisEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-5679-0297
Piyush MaitiEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Jiaxiuxiu ZhangEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Ganna BlazhenetsEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Salma RochaEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Ranjani ShankarEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Alinda AmuiriEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Dustin B HammersDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0002-1644-2618
Ani EloyanDepartment of Biostatistics, Brown University, Providence, RI, USA.
Kala KirbyDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Robert A KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Paul AisenAlzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA, USA.
Laurel BeckettDepartment of Public Health Sciences, University of California Davis, Davis, CA, USA.
Walter A KukullDepartment of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Arthur W TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, CA, USA.
Alireza AtriBanner Sun Health Research Institute, Sun City, AZ, USA.
David G ClarkDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Gregory S DayDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Ranjan DuaraWien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Ian GrantDepartment of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lawrence S HonigTaub Institute and Department of Neurology, Columbia University Irving Medical Center, NewYork, NY, USA.
Erik C B JohnsonDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
David T JonesDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0002-4807-9833
Joseph C MasdeuNantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, TX, USA.ORCID https://orcid.org/0000-0001-9955-6954
Mario F MendezDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Erik MusiekDepartment of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID https://orcid.org/0000-0002-8873-0360
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Meghan RiddleDepartment of Psychiatry, Alpert Medical School, Brown University, Providence, RI, USA.
Emily RogalskiHealthy Aging & Alzheimer's Research Care Center, Department of Neurology, University of Chicago, Chicago, IL, USA.
Stephen SallowayDepartment of Psychiatry, Alpert Medical School, Brown University, Providence, RI, USA.
Sharon J ShaDepartment of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA.
Raymond Scott TurnerDepartment of Neurology, Georgetown University, Washington, DC, USA.
Thomas S WingoDepartment of Neurology, University of California, Davis, Sacramento, CA, USA.ORCID https://orcid.org/0000-0002-7679-6282
David A WolkDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kyle B WomackDepartment of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Kelly Nicole Holohan NudelmanDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Alexandra TouroutoglouDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0001-7916-622X
Prashanthi VemuriDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0003-4286-0589
Jacob W VogelDepartment of Clinical Sciences Malmö, Faculty of Medicine, SciLifeLab, Lund University, Lund, Sweden.
Suzanne M DufaultDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Thomas J HoffmannDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Maria C CarrilloMedical & Scientific Relations Division, Alzheimer's Association, Chicago, IL, USA.
Bradford C DickersonDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-5958-3445
Liana G ApostolovaDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Gil D RabinoviciEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Renaud La JoieEdward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0003-2581-8100
Funding
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3MResearch Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3MEarly Onset Alzheimer's Disease ConsortiumR56AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2017 to 2017
$7.7MNIA NIH HHS P30 AG072977NIA NIH HHS R56 AG057195NIA NIH HHS U01 AG057195
Abstract
The growing availability of large-scale biomarker datasets has allowed data-driven methods to characterize Alzheimer's disease biological heterogeneity. However, most prior studies have focused on cohorts of late-onset amnestic cases, leaving early-onset Alzheimer's disease underexplored. We aimed to characterize tau-PET-based subtypes through a robust data-driven approach in the Longitudinal Early-Onset Alzheimer's Disease Study. Baseline [
Indexed as
atypical Alzheimer's diseasedata-driven clusteringdisease heterogeneityneuroimaging biomarkersvoxel-wise modelling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.