ArticleFrontiers in pediatrics2026
DENTALE: a validated Dentofacial EvaluatioN Tool to standardize radiological Assessment of Late dental and maxillofacial adverse Effects following treatment for pediatric rhabdomyosarcoma.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Editorial: Understanding oral health challenges in pediatric and adult cancer care.Frontiers in oncology · 2026Article
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Authors and funding
16 authors.
Funding
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Abstract
Objectives: The treatment of childhood cancers causes significant late dental adverse effects, which are evident on radiographic imaging and potentially affect future function. Currently, no standardized tool exists for objectively assessing these effects. This study aimed to develop and validate a new radiographic evaluation tool, "DENTALE," to guide dental care for survivors and aid research on late dental effects. Methods: This cross-sectional validation study employed a systematic tool development approach, following established guidelines. The tool was developed through orthopantomogram (OPG) assessment by three dentists using 10 cases of head and neck rhabdomyosarcoma survivors with a wide range of dental abnormalities. Development validation was conducted through the evaluation of 14 OPGs by three independent dentists. Interobserver reliability was assessed using intraclass correlation coefficients (ICCs). Content validity was established through expert consensus, and clinical utility was evaluated using sensitivity and specificity analyses for referral decision-making. This was later validated in a larger cohort ( Results: The key anatomical features evaluated by the tool are as follows: the morphological condylar process, mandibular ascending ramus, alveolar process, tooth presence, and tooth morphology. Interobserver reliability demonstrated good to excellent agreement (ICC: 0.857-0.939, 95% CI: 0.66-0.98). Using a threshold score of 16 points, the tool achieved 100% sensitivity and 90.0% specificity for specialized dental care referral decisions, with positive and negative predictive values of 94.6% and 100%, respectively. Conclusions: DENTALE offers a validated and practical radiographic scoring system for OPGs, enabling both clinicians and researchers to assess objectively late dental adverse effects following childhood cancer treatments. Clinical significance: This tool supports evidence-based referral to specialized dental healthcare, thereby supporting patient management. Furthermore, by standardizing methodology and reporting research on dental late effects, DENTALE can facilitate comparisons across treatments and treatment modalities.
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