Analysis of pathogen distribution and risk factors for extended antibiotic course in children with microbiological-based protracted bacterial bronchitis in southwest China.

Donghai Wang, Su Yang, Yajun Mou, Xingling Pu, Qiumeng Xiang, Jianchuan Chen, Zhou Fu, Jihong Dai

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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Donghai WangDepartment of Respiratory Disease, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.

Su YangDepartment of Pediatrics, Longchang City Maternal and Child Health Care Hospital, Longchang, China.

Yajun MouDepartment of Pediatrics, the People's Hospital of Dejiang City, Tongren, China.

Xingling PuDepartment of Pediatrics, Tengchong City Maternal and Child Health Care Hospital, Tengchong, China.

Qiumeng XiangDepartment of Prophylactic Vaccination, Chongqing Youyoubaobei Woman and Children's Hospital, Chongqing, China.

Jianchuan ChenDepartment of Respiratory Disease, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.

Zhou FuDepartment of Respiratory Disease, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.

Jihong DaiDepartment of Respiratory Disease, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prior studies of protracted bacterial bronchitis (PBB) in children were mainly conducted in high-income areas, and no data from low- and middle-income countries have been published. In this study, we aimed to clarify the outcomes of PBB in a larger cohort in southwest China, focusing on the pathogen distribution and risk factors with an extended course of antibiotics. Methods: Children with PBB who underwent flexible bronchoscopy were included. Clinical review, cytologic examination, and semiquantitative bacterial culture of bronchoalveolar lavage fluid (BALF) were performed as clinically indicated. Multiple linear regression and decision tree analyses were used to determine factors with an extended course of antibiotics. Results: The study included 138 children. Two pathogens were detected in 23 BALF samples. Conclusion: The most prevalent pathogen in children with PBB in southwest China was

Indexed as

corticosteroidscourse of antibioticsinfluence factorsprotracted bacterial bronchitisstreptococcus pneumoniae

Identifiers

PMID42255901

DOI10.3389/fped.2026.1747356

PMCPMC13236680

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