ArticleFrontiers in pediatrics2026
Multivariate risk assessment and analysis of brain injury in high-risk infants in neonatal intensive care unit.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To explore risk factors, establish, and validate a risk prediction model for brain injury in high-risk infants in neonatal intensive care units (NICU). Methods: A case-control study was conducted involving 819 high-risk infants admitted to the Second People's Hospital of Wuhu City from March 2019 to March 2023. Participants were divided into a modeling group ( Results: Meconium-stained amniotic fluid (MSAF), neonatal respiratory distress syndrome (NRDS), and pregnancy-associated anemia were independent risk factors for brain injury ( Conclusion: Meconium-stained amniotic fluid (MSAF), NRDS, pregnancy-associated anemia, and low umbilical artery PH, and low BE are independent risk factors for brain injury. A higher 5-minute Apgar score and elevated serum levels of BDNF and 25(OH)D are protective factors. The risk prediction model established on the basis of Papile, Volpe, and Sarnat standardized criteria shows favorable performance and can be used for early risk stratification of brain injury in high-risk NICU infants.
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