ArticleCureus2026
Acute Coronary Syndrome in Alpha-Gal Syndrome: A Rare Immune-Cardiac Intersection.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity reaction to galactose-α-1,3-galactose (alpha-gal) following exposure to lone star tick bites. While classically associated with anaphylactic and delayed gastrointestinal-predominant allergic reactions to mammalian meat products, emerging evidence suggests an association between alpha-gal sensitization and accelerated coronary atherosclerosis. This case is presented to highlight the potential cardiovascular implications of AGS and its impact on acute coronary syndrome presentation and management. We report a case of a 51-year-old man with a medical history significant only for AGS who presented with a two-day history of severe retrosternal chest pain radiating to the left shoulder. Electrocardiography revealed ST-segment elevations in the inferior leads and severely elevated high-sensitivity troponin levels, prompting activation of an ST-elevation myocardial infarction protocol. Emergent coronary angiography revealed a 100% occlusion of the distal right coronary artery and a 90% stenosis of a marginal artery. Successful percutaneous coronary intervention was performed, followed by a staged intervention guided by intravascular ultrasound. Given the patient's AGS, bivalirudin was used for anticoagulation to avoid porcine- or bovine-derived heparin products. This case supports a growing body of evidence linking AGS with coronary atherosclerosis and acute coronary syndrome. It highlights AGS as a potential isolated risk factor for coronary artery disease and underscores the importance of individualized diagnostic and therapeutic decision-making in affected patients.
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