ArticleCureus2026
Necrotising Fasciitis: A 10-Year Retrospective Cohort of Outcomes and Correlation to the Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) Score in a Single-Centre District General Hospital in the United Kingdom.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Necrotising fasciitis (NF) is a life-threatening soft-tissue infection associated with high morbidity and mortality. The Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) score was developed to aid early diagnosis, but its association with clinical outcomes remains uncertain. Most existing data originate from tertiary referral centres. This study evaluated clinical outcome, LRINEC score performance, and surgical timing in NF cases managed in a district general hospital in the United Kingdom over a 10-year period. Methodology This retrospective cohort study followed STROBE guidelines and included 48 adult patients with surgically confirmed NF (clinical features, laboratory parameters, intraoperative findings, and/or histopathological confirmation) treated between January 2013 and December 2023. Variables collected included demographics, comorbidities, LRINEC scores, time to first debridement, number of surgical debridements, intensive care unit (ICU) admission, hospital length of stay, and in-hospital mortality. Statistical analysis included chi-square or Fisher's exact tests, non-parametric comparisons (Kruskal-Wallis test, Mann-Whitney U test), and Spearman's correlation analyses, with statistical significance set at p-values <0.05. Owing to sample size, analyses were exploratory and unadjusted; multivariable modelling was not performed. The study was registered and approved as a Clinical Audit by the Trust Clinical Audit Review Panel (reference: 7926). Individual consent was waived as anonymised retrospective audit data were used. Results The mean patient age was 62.2 years (SD = 12.1), with 56.2% male predominance (27/48). Lower limbs were affected in 83.3% (40/48) of cases. Mean LRINEC score was 7.9 ± 2.3, with 66.7% (32/48) classified as high-risk (≥8). Overall mortality was 27.1% (13/48), and 81% (39/48) required ICU admission. Mean hospital stay was 24.3 ± 18.6 days; patients required an average of 3.0 ± 1.4 surgical debridements. Group A
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.