Evidence map›Paper›PMID 42255740›Full record

ArticleCureus2026

Apathetic Thyroid Storm Presenting as New-Onset Dilated Cardiomyopathy and Cardiogenic Shock.

Pragya Bhandari, Tark Abou-Elmagd, Shreebridhi Pande, Nirajan Kandel, Inmaculada Ncogo Alene

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pragya BhandariInternal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
Tark Abou-ElmagdInternal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
Shreebridhi PandeInternal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
Nirajan KandelInternal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
Inmaculada Ncogo AleneInternal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid storm is an uncommon but life-threatening endocrine emergency associated with high mortality, and its diagnosis remains largely clinical due to the lack of universally reliable criteria to distinguish it from severe thyrotoxicosis; atypical or "apathetic" forms are particularly rare and can delay recognition. A 49-year-old man with no prior medical history presented with a two-week history of progressive anasarca, palpitations, and nonspecific gastrointestinal symptoms in the absence of fever or agitation and was found to have atrial fibrillation with rapid ventricular response and decompensated heart failure. Laboratory studies showed a suppressed thyroid-stimulating hormone with markedly elevated free T3 and T4, while echocardiography revealed global hypokinesis with an ejection fraction of 25-30%. His Burch-Wartofsky score of 60 supported the diagnosis of thyroid storm. Despite progression to cardiogenic shock, he improved with rate control, aggressive diuresis, esmolol, methimazole, and glucocorticoids without requiring inotropic support; subsequent outpatient evaluation confirmed Graves' disease, and at one year, he remains euthyroid with recovering ventricular function. This case highlights that apathetic thyroid storm may present predominantly with severe cardiomyopathy and shock in the absence of classic hyperadrenergic signs, underscoring the importance of early recognition and prompt targeted therapy for favorable outcomes.

Indexed as

cardiogenic shockcardiomyopathynonischemic cardiomyopathythyroid stormthyrotoxicity

Identifiers

PMID42255740
PMCPMC13241225

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.