ArticleCureus2026
Excessive Sedation and Catatonia-Like Presentation From Risperidone-Valproate Interaction: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sedation is a known adverse effect of risperidone, but catatonia-like immobility potentiated by valproate is rarely reported. A 23-year-old woman with bipolar disorder, admitted for acute psychosis, was treated with risperidone titrated to 3 mg twice daily alongside valproate. She developed escalating somnolence, immobility, refusal of food, and tremors. Laboratory evaluation revealed a supratherapeutic valproate level (125 µg/mL); medical workup and a lorazepam challenge were unrevealing. Discontinuation of risperidone with substitution with olanzapine resulted in rapid and complete recovery within 24 hours. This case highlights the risk of severe catatonia-like sedation from a risperidone-valproate interaction. It underscores the importance of recognizing medication-induced causes of catatonia-like presentations to enable timely intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.