Evidence map›Paper›PMID 42255648›Full record

ArticleACS omega2026

Design, Synthesis, and Biological Evaluation of Novel Tetrandrine Derivatives Targeting AKT1 for Hepatocellular Carcinoma Therapy: Integration of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Validation.

Hongbao Hou, Ruiqi Fan, Tao Wang, Yukun Lin, Yi Zhang, Qingxuan Zeng, Yun-Feng Liu

Erratum issuedAbstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Hongbao HouDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, People's Republic of China.ORCID https://orcid.org/0000-0001-9086-466X
Ruiqi FanDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, People's Republic of China.
Tao WangDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, People's Republic of China.
Yukun LinDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, People's Republic of China.
Yi ZhangDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, People's Republic of China.
Qingxuan ZengDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, People's Republic of China.
Yun-Feng LiuDepartment of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan 030001, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To discover novel and effective potential anticancer agents, 24 novel 14N-substituted tetrandrine (Tet) derivatives were synthesized and investigated for their effects on antiproliferative activities against human cancer cell lines HepG2 and A549 by the MTT method. Compound

Identifiers

PMID42255648
PMCPMC13234798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.