Evidence map›Paper›PMID 42255622›Full record

ArticleACS omega2026

Unveiling the Structural Modifications of Cyanines to Target G‑Quadruplex DNA through Biophysical, Computational, and Transcriptome Analyses.

Cristina Galiana-Roselló, Andrea Lázaro-Gómez, Ariadna Gil-Martínez, Anargyros Drolapas, William E Meador, Catalina Nicolau, Chun-Qiong Zhou, Jared H Delcamp, Antonio Bauza, Jorge González-García

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cristina Galiana-RosellóDepartment of Inorganic Chemistry, Institute of Molecular Science (ICMol), University of Valencia, Catedrático José Beltrán 2, Paterna 46980, Spain.
Andrea Lázaro-GómezDepartment of Inorganic Chemistry, Institute of Molecular Science (ICMol), University of Valencia, Catedrático José Beltrán 2, Paterna 46980, Spain.
Ariadna Gil-MartínezDepartment of Inorganic Chemistry, Institute of Molecular Science (ICMol), University of Valencia, Catedrático José Beltrán 2, Paterna 46980, Spain.
Anargyros DrolapasDepartment of Inorganic Chemistry, Institute of Molecular Science (ICMol), University of Valencia, Catedrático José Beltrán 2, Paterna 46980, Spain.
William E MeadorMaterials and Manufacturing Directorate (RXNC), Air Force Research Laboratory, 2230 Tenth Street B655, Wright-Patterson AFB, Ohio 45433, United States.ORCID https://orcid.org/0000-0002-9869-026X
Catalina NicolauDepartment of Chemistry, Universitat de les Illes Balears, Crta de Valldemossa Km 7.5, Palma de Mallorca, Baleares 07122, Spain.
Chun-Qiong ZhouSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China.ORCID https://orcid.org/0000-0002-1289-6719
Jared H DelcampMaterials and Manufacturing Directorate (RXNC), Air Force Research Laboratory, 2230 Tenth Street B655, Wright-Patterson AFB, Ohio 45433, United States.ORCID https://orcid.org/0000-0001-5313-4078
Antonio BauzaDepartment of Chemistry, Universitat de les Illes Balears, Crta de Valldemossa Km 7.5, Palma de Mallorca, Baleares 07122, Spain.ORCID https://orcid.org/0000-0002-5793-781X
Jorge González-GarcíaDepartment of Inorganic Chemistry, Institute of Molecular Science (ICMol), University of Valencia, Catedrático José Beltrán 2, Paterna 46980, Spain.ORCID https://orcid.org/0000-0001-8994-1779

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Six cyanine ligands differing in the polymethine linker and the substituents have been developed and investigated as binders for DNA. The interaction with DNA was assessed by fluorescence resonance energy transfer (FRET) melting, UV-vis, and fluorimetric assays and completed with computational experiments. The ligand containing a shorter linker of one carbon length shows no interaction, while increasing the linker length enhances the interaction toward G-quadruplex DNA structures. The largest binding is observed for the cyanines containing five carbon connectors, while the change of the electronic nature of the substituents has no significant effect on the binding to G4s. The binding modes show a preference for the

Identifiers

PMID42255622
PMCPMC13234662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.