ArticleACS omega2026
A Green and Sustainable Approach for Melatonin Determination: Comparative Assessment of Hybrid Micellar Liquid Chromatography and Differential Pulse Voltammetry.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Melatonin, the main indolamine compound in the pineal gland, which plays a role in the regulation of biological rhythms and shows promise in the treatment of sleep disorders, is widely used today. In this study, the determination of melatonin in tablet formulations was comparatively evaluated using hybrid micellar liquid chromatography (HMLC) and differential pulse voltammetry (DPV) methods. The compound was analyzed by the HMLC method in a water-ethanol binary mixture containing 0.05 M sodium dodecyl sulfate and 20% ethanol (v/v) adjusted to pH 7.5. It was then determined by the DPV method using a gold electrode in Britton-Robinson buffer (pH 5.0). The results were systematically analyzed, the analytical methods were validated, and a comprehensive comparison was conducted. Under optimized conditions, the HMLC method yielded melatonin concentrations between 2.0 and 8.0 μg/mL (
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